GO:0070265 biological_process necrotic cell death
| PAG Title | GO:0070265 biological_process necrotic cell death |
| PAG ID | TAX028833 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. |
| Species | Homo sapiens |
| nCoCo Score | 463 |
| Base PAG ID | TAX028833 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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